HYPERHIDROSIS PRESCRIPTION
The oxybutynin gel is a prescription-grade treatment developed with expert dermatologists to deliver targeted, full-body sweat control. Fast-absorbing, invisible on skin, aluminum-free, and crafted for the way you actually live.
Oxybutynin
Oxybutynin is a prescription anticholinergic that helps reduce excessive sweating by blocking overactive nerve signals (acetylcholine) that activate sweat glands. Applied topically, it targets sweating right where it happens - while potentially minimizing the systemic side effects of oral medications.
Studies have shown topical oxybutynin can reduce sweating by over 70% with consistent use, significantly improving quality of life.¹
Twofold Gel Base
A proprietary transdermal delivery system engineered to enhance skin absorption and ensure even, consistent distribution. Designed for quick-drying comfort and optimized penetration, it helps the active ingredient reach the sweat glands more effectively - all while leaving skin smooth and residue-free.
¹Topical oxybutynin for hyperhidrosis: A systematic review Wallace,
Carly E. et al. JAAD Reviews, Volume 2, 145 - 148
Dermatologist
Consultation
Clinically Backed
Solutions
Once-Daily
Treatment
30-Day Guarantee
We know you’ve probably tried more than a few treatments-and might be skeptical about trying something new. To make it easier, we offer a 30-day satisfaction guarantee.
Pause, skip, or cancel your subscription anytime
Apply your medication daily, exactly as prescribed by your healthcare provider. This product may be used once daily at night, just before bed. Apply an even layer, and gently rub it in until fully absorbed (2-3 minutes).
For best results, apply to clean, dry skin and allow the gel to fully dry before dressing or lying down. Most people begin noticing results within 2-4 weeks of consistent use.
Helpful tip: Apply only to the areas you want to treat (underarms, hands, feet, or face). Avoid applying immediately after shaving or to irritated skin.
Free Online Consult
Free Expedited Delivery
Only Pay If Approved
Prescription-Strength Care
Formulated by Experts
OUR GROWING COMMUNITY
“
I didn’t know my hands could feel like this!
I've had sweaty palms since I was a teenager and can't remember the last time I shook someone's hand without feeling severe anxiety... now I don't even have to worry about it. I wish I had this product ten years ago!
“
No more shirt changes throughout the day
I used to bring extra shirts to the office, but now I can wear the same one all day. I’ve been using it nightly without side effects, and it’s gentler on my skin than any antiperspirant I’ve tried (plus it’s aluminum-free).
“
Nothing slips out of my hands anymore!
I could never hold ANYTHING - my phone, the steering wheel, pens - all slipped through my hands. Sweating made my everyday feel unnecessarily difficult. Thanks to Twofold for actually seeing this as a problem and delivering a solution that works!
“
Dry and less smelly feet
I can’t believe how well this worked. It took 6 nights, but I finally woke up and my feet were completely dry - no sweat at all. It’s such a different feeling than I’m used to and while I do sweat a little still, it’s nothing like it used to be.
“
I can wear grey again
I can actually wear normal clothes again instead of just black or multiple coats and cardigans to hide my pit stains. I feel like I’m getting my life back now. Know that I’ll be a lifelong fan and user.
THE DATA
13x
Less likely to cause potential side effects compared to oral medications
92%
Experienced significant improvements in their quality of life within 4 weeks
9+
Targeted body areas for simple application
0%
Aluminum in our formula
WHY IT WORKS BETTER
Topical oxybutynin application may result in 13x fewer side effects by minimizing unnecessary absorption into the bloodstream.
Designed for a modern lifestyle, our formula absorbs within minutes and leaves zero residue for a once-nightly application.
Our gel is engineered with a vehicle that allows the active medication to move past the surface and work directly at the root of the sweat gland.
HOW IT WORKS
Find answers to common questions about our products and treatments.
What is Twofold?
Twofold is a virtual sweat clinic dedicated to helping people manage their hyperhidrosis, or excessive sweating. We provide treatment plans designed by licensed providers to address excessive sweating. Twofold is all about making expert sweat care simple, effective, and accessible—delivered straight to your door without the need for in-person visits.
What's the process to get care with Twofold?
Twofold simplifies the process of managing hyperhidrosis with personalized care:
Start with an Online Consultation
Complete a quick, secure questionnaire about your symptoms, medical history, and treatment goals.
Receive Your Treatment at Home
If approved by your Twofold provider, your treatments will be compounded and shipped directly to your door in discreet packaging—no need for in-person visits.
Ongoing Support
You’ll have unlimited access to your care team for follow-up questions or adjustments to your treatment plan, all through the Twofold portal.
When will I notice a difference, and how long will the results last?
It usually takes about 4 weeks of daily use to see full, consistent results — so don’t worry if it feels slow a first. Many people will notice changes within their first 1–2 weeks, and it should keep improving from there. Consistent use of your prescribed medication is key to achieving and maintaining the best results. Individual response times can vary based on the severity of your hyperhidrosis and the area being treated.
Is this treatment FDA-approved and supported by science?
Oxybutynin, the primary ingredient in our treatment, is FDA-approved for several medical uses, but its use for treating hyperhidrosis is considered "off-label" in the U.S. Off-label prescriptions are a common and legal practice used when providers determine that a treatment is medically appropriate based on a patient's needs. While oxybutynin's use in hyperhidrosis is off-label, it's widely prescribed by dermatologists due to its efficacy in reducing excessive sweating. Many studies have demonstrated the safety and efficacy of oxybutynin, and it has become a well-established treatment among specialists in the field. Our treatment plans are informed by existing research and customized by licensed providers to ensure you receive the best possible care.
How much does treatment cost, and is it covered by insurance?
Twofold offers quarterly subscription-based treatment plans, at $150 for 3 months of treatment. Shipping is always free, and there are no hidden fees. Currently, Twofold does not accept insurance. This allows us to provide greater transparency without surprise costs, copays, or hidden fees.
